ea0081p548 | Calcium and Bone | ECE2022
Dahir Kathryn M.
, Angel Martos-Moreno Gabriel
, Linglart Agnes
, Petryk Anna
, Kishnani Priya S.
, Rockman-Greenberg Cheryl
, Martel Samantha E.
, Ozono Keiichi
, Hogler Wolfgang
, Seefried Lothar
Background: Hypophosphatasia (HPP) is a rare, inherited metabolic disease caused by deficient activity of tissue nonspecific alkaline phosphatase (TNSALP).Methods: Baseline/pretreatment data from the Global HPP Registry were analyzed to compare HPP disease burden between adults (≥18 years of age) with skeletal manifestations (history of rickets, biopsy-proven osteomalacia, recurrent or poorly healing fractures/pseudofractures, etc; Skeletal group) ...